Extracellular Superoxide Dismutase in Insects
نویسندگان
چکیده
منابع مشابه
Extracellular Superoxide Dismutase
Extracellular-superoxide dismutase is a tetrameric copper-containing glycoprotein that previously has been demonstrated to be the major superoxide dismutase of human extracellular fluids. The occurrence of this enzyme in various human tissues that were removed from two accidental death victims and in 19 different human cultured cell lines was determined. All investigated tissues were found to c...
متن کاملInactive extracellular superoxide dismutase disrupts secretion and function of active extracellular superoxide dismutase.
Extracellular superoxide dismutase (EC-SOD) is an antioxidant enzyme that protects cells and tissues from extracellular damage by eliminating superoxide anion radicals produced during metabolism. Two different forms of EC-SOD exist, and their different enzyme activities are a result of different disulfide bond patterns. Although only two folding variants have been discovered so far, five foldin...
متن کاملExpression of Extracellular Superoxide Dismutase in Atherosclerosis
We characterized a novel form of extracellular superoxide dismutase (ecSOD) in atherosclerotic vessels. Specific activity and protein expression of ecSOD was increased twoto threefold in apo E–deficient compared with control aortas. RNase protection assays demonstrated that the expected ecSOD transcript was not increased in either apo E–deficient mice or cholesterol-fed LDL receptor–deficient m...
متن کاملExtracellular superoxide dismutase polymorphism in mice.
OBJECTIVE In this study, we describe a previously unrecognized murine extracellular superoxide dismutase (ecSOD) allele and examine its distribution among various strains and its effect on the ecSOD phenotype. METHODS AND RESULTS Polymerase chain reaction analysis of genomic and cDNA from apolipoprotein E/LDLR-/- mice indicates the presence of 2 distinct transcripts for this enzyme independen...
متن کاملRole of extracellular superoxide dismutase in hypertension.
We previously found that angiotensin II-induced hypertension increases vascular extracellular superoxide dismutase (ecSOD), and proposed that this is a compensatory mechanism that blunts the hypertensive response and preserves endothelium-dependent vasodilatation. To test this hypothesis, we studied ecSOD-deficient mice. ecSOD(-/-) and C57Blk/6 mice had similar blood pressure at baseline; howev...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2011
ISSN: 0021-9258
DOI: 10.1074/jbc.m111.288845